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What causes osteogenesis imperfecta (oi) Oi can also cause weak muscles,. Oi is caused by defects in or related to a protein called type 1 collagen

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Collagen is an essential building block of the body Sometimes the fractures happen for no known reason The body uses type 1.

People with osteogenesis imperfecta break bones easily, with little or no force causing the break

It can also cause a curved spine, muscle weakness, difficulty breathing and. Osteogenesis imperfecta (oi), also known as brittle bone disease, is an inherited disorder of the connective tissue A child born with oi may have soft bones that fracture easily, bones that are. Osteogenesis imperfecta can be caused by mutations in one of several genes

Mutations in the col1a1 and col1a2 genes cause approximately 90 percent of all cases Osteogenesis imperfecta (oi) is a genetic disorder that causes a person's bones to break easily, often from little or no apparent trauma Oi is also called brittle bone disease. oi. Though anyone can be born with oi, people with a family history of the disease are at greater risk of inheriting the disease through an.

The most frequent causes of oi are changes (mutations) in the two genes that make type i collagen, col1a1 or col1a2

The collagen molecules they code. These types are caused by changes in genes that code for proteins that interact with collagen In all types of osteogenesis imperfecta, symptoms vary greatly from one individual to. Osteogenesis imperfecta is caused by a faulty gene that affects the body's ability to produce collagen

The quantity of collagen produced is either lower or of a poorer quality Osteogenesis imperfecta (oi) is a genetic disorder in which bones fracture (break) easily