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The aim of the present study was to identify candidate genes involved in ovarian cancer platinum response by analysing genes from homologous recombination and fanconi anaemia pathways. The validation results of the six candidate genes have. We selected a total of six candidate genes (fanca, fancg, pold1, kdm1a, blm and brca1) for subsequent verification
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The validation results of the six candidate genes have significance in. In this review we summarize how these challenges have been addressed over the last decade, with a particular focus on the integration of gwas results with functional genomics datasets. The aim of this study was twofold
(1) to investigate the applicability of cvat to rank genes within a set of associated genes
And (2) to provide functional validation for the findings of. In this chapter, we aim at providing both simple theoretical aspects underlying three main options at disposal toward the identification and validation of candidate genes from gwas. Exploiting the statistical associations coming out from a gwas experiment to identify and validate candidate genes may be potentially difficult and time consuming.
