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Author information departments of anesthesiology and pharmacology, the university of michigan medical center, ann arbor,. Its pharmacology was reported in detail by domino, chodoff and corssen in 1965.4 the data presented to the licensing authorities were based on over 12 000 administrations, with a 13%. Introduction fifty years ago, corssen and domino (1966) published the first clinical study of ketamine as a human anesthetic

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Ketamine produces an unusual state, sometimes. Ketamine hydrochloride is a parenteral anaesthetic agent which has been claimed to produce profound analgesia (domino, chodoff and corssen, 1965) On august 3, 1964, dr

Edward domino and his colleague anesthesiologist dr

Domino and corssen also collaborated on the first clinical trial of ketamine They published results in 1966 showing ketamine was a safe anesthetic in the 130 subjects undergoing. Literatur corssen, g., and e