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In human brain, cd22 is expressed in oligodendrocytes, its receptor on microglia There is a protective cd33. Binding of scd22 to igfr2 scrambles lysosomal trafficking, and lipids build up
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Blocking this binding restored lysosomal function. One is cd33, a known ad gene that encodes another transmembrane receptor on these cells Cd22 suppresses microglial phagocytosis—a new therapeutic target
Elucidate previously unappreciated roles for cd22 in the aging brain
Taken together, the new genetic associations emphasize the primacy of app processing and innate immunity for ad pathogenesis 5 apr 2019 could cd33 be the microglial target for stimulating phagocytosis 23 apr 2019 deleting cd33 benefits mice—if their microglia express trem2 11 jul 2019 risk gene conspiracy Clusterin binds cd33, souring microglial taste for aβ 18 apr 2023
Further reading news cd22 suppresses microglial phagocytosis—a new therapeutic target 5 apr 2019 cd22 suppresses microglial phagocytosis—a new therapeutic target 23 apr 2019 deleting cd33 benefits mice—if their microglia express trem2 11 jul 2019 5 apr 2019 'runner plasma' jogs neurogenesis, quells neuroinflammation in mice 27 sep 2019 neurogenesis tapers in older brains, but plummets in alzheimer’s 25 mar 2019 neurogenesis wanes in alzheimer’s, along with cognition 24 may 2019
Much of the research on microglia in alzheimer’s disease has focused on the trem2 receptor (see part 4 of this series)
