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在发育和分化过程中基因的表达涉及许多顺式调控DNA元件和反式作用蛋白的复杂机制的调控。 调节基因转录的顺式调控DNA元件是启动子，绝缘子，增强子和沉默子。 最近，一类被称为 增强. Graphical abstract enhancer rna (erna) can play a key role in cancer initiation and progression Regulatory elements, including negative elongation factor (nelf) and enhancer rna (erna) control transcription of a gene into messenger rna in metazoans (animals).
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As erna is produced from the active transcription of enhancers and is involved in the regulation of cell fate, its manipulation will influence cell function, and therefore, it can be a new target for. 一步说明eRNA在人类疾病复杂调控机制中发挥重要作用。 然而, 目前关于eRNA 的研究并不多, 大部分eRNA 的功能和作用仍然不明确, 因此, eRNA的表达和功能研究是一个重要而迫切的问题。本文. Here, we review recent insights into the biogenesis of ernas and the mechanisms underlying their multifaceted functions and consider how these findings could inform future.
一类被称为增强子RNA（eRNA）的增强子转录的ncRNA被发现，eRNA的长度为0.5-5kb，因此可以分类为lncRNA。 在发育和分化过程中基因的表达涉及许多顺式调控DNA元件和反式.
本研究通过综合分析来自超过10,000个TCGA样本的eRNA表达数据与肿瘤浸润免疫细胞的丰度，发现eRNA的表达与免疫细胞类型的分布关系。 Enhancer rna (erna) is a type of transcribed rna from distal enhancers, which plays key roles in transcription regulatory circuitry to mediate the activation of target gene. 该研究首次建立了增强子RNA（enhancer RNA, eRNA）关联分析方法 (eRNA-TWAS), 并用于鉴定eRNA关联的癌症风险基因，为癌症遗传病因学研究提供了新的视角和潜在的治疗靶点。
